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Caspase-Activated DNase (CAD) is a protein codified by a gene with 338 nucleotides located in a particular position on chromosome 1 (location 1p36.3). In addition, it breaks up the DNA during apoptosis and promotes the cell differentiation. CAD and ICAD forms.png Despite this gene being present in every cell, this protein is only expressed in different tissues and cell variety such as pancreas, heart, colon, leukocytes, prostate, ovary, placenta, kidney, spleen and thymus.〔(【引用サイトリンク】url=http://www.bio.davidson.edu/Immunology/Students/spring2006/Ryan/YFIP.html )〕 It is also known as Caspase Activated Nuclease (CPAN), DNA Fragmentation Factor 40 (DFF-40), DFF2 and DFFB. Besides, there are other nomenclatures as a result of combining the previous ones.〔 == Structure == This heterodimer is an endonuclease〔 with a high content of cysteine residues.〔 It remains inactive in growing cells while it is associated with its inhibitor (ICAD, DNA fragmentation factor 45 kDa subunit, DFFA or DFF45) resulting into a complex ICAD-CAD.〔〔〔〔 Their dissociation allows DFF40 to oligomerize to form a large functional complex which is by itself an active DNase.〔〔〔〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Caspase-activated DNase」の詳細全文を読む スポンサード リンク
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